MOLECULAR PATHWAYS IDENTIFIED FROM SINGLE NUCLEOTIDE POLYMORPHISMS DEMONSTRATE MECHANISTIC DIFFERENCES IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS OF ASIAN AND EUROPEAN ANCESTRY

Abstract Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component.Individuals of Asian-Ancestry (AsA) disproportionately experience more severe SLE compared to individuals of European-Ancestry (EA), including increased renal involvement and tissue damage.However, the mechanisms underlying elevated s

In this research, an inexpensive aerodynamic shape optimization of airfoil is performed for Darrieus type vertical axis wind turbine (VAWT).Computational fluid dynamics (CFD) evaluations of various airfoil shapes are treated inexpensively by considering the apparent flow velocity magnitudes and apparent angles of attack at multiple positions of VAW

ABSTRACT Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for several significant outbreaks of debilitating acute and chronic arthritis and arthralgia over the past decade.These include a recent outbreak in the Caribbean islands and the Americas that caused more than 1 million cases of viral arthralgia.Despite the major impact o

Acute stress responsiveness is a quantitative trait that varies in severity from one individual to another; however, the genetic component underlying the individual variation is largely unknown.Fischer 344 (F344) and Wistar Kyoto (WKY) rat strains show large differences in behavioral responsiveness to acute stress, such as freezing behavior in resp

Background Patients with schizophrenia who are not acutely ill continue Pouch to experience different levels of psychopathology, despite a relatively stable lifestyle.Aims To describe the pattern of symptoms in patients with schizophrenia attending an outpatient clinic using the Brief Psychiatric Rating Scale Expanded version (BPRS-E).Methods Conse